Matrix and cell phenotype differences in Dupuytren’s disease

Table 1 Median expression levels and fold change of all genes analyzed in Dupuytren’s nodule and matching cord tissue. p value determined by Wilcoxon paired rank test

Gene symbol	N	Mean cord	Mean nodule	Fold change nodule/cord	p value
ADAMTS14	8	0.0041	0.0124	2.988	0.0234
ADAMTS2	8	0.2375	0.2983	1.256	n.s.
ADAMTS3	6	0.0025	0.0032	1.321	n.s.
BGN	8	1.2588	1.5649	1.243	n.s.
BMP1	8	0.0424	0.0556	1.312	n.s.
COL1A1	8	4.2939	10.7051	2.493	0.0078
COL1A2	8	2.6263	4.7832	1.821	0.0078
COL3A1	8	3.7696	7.8217	2.075	n.s.
COL4A1	6	0.1868	0.1972	1.152	n.s.
COL5A1	8	0.3198	0.6450	2.017	0.0156
COL6A1	8	2.5967	4.1680	1.605	0.0234
COLGALT1	7	0.0386	0.0415	1.098	n.s.
CTSK	7	0.1254	0.1927	1.742	0.0313
DCN	8	0.7646	0.6807	0.890	n.s.
DDR1	6	0.0082	0.0068	0.768	n.s.
DDR2	8	0.0540	0.0421	0.780	0.0391
ELN	8	0.0959	0.1054	1.099	n.s.
FKBP10	8	0.1019	0.1440	1.414	0.0234
FMOD	8	0.1868	0.1334	0.714	n.s.
FN1	8	1.9316	3.4849	1.804	0.0078
LEPRE1	8	0.0140	0.0182	1.304	n.s.
LEPREL1	8	0.0023	0.0023	1.019	n.s.
LEPREL2	8	0.0154	0.0271	1.759	0.0156
LOX	7	0.0425	0.0603	1.597	0.0156
LOXL1	8	0.0400	0.0555	1.388	n.s.
LOXL2	8	0.1436	0.2461	1.714	n.s.
LOXL3	7	0.0067	0.0057	0.782	n.s.
LOXL4	8	0.0015	0.0009	0.574	n.s.
MMP1	4	0.0004	0.0003	0.839	n.s.
MMP13	6	0.0015	0.0023	1.302	n.s.
MMP14	8	0.3076	0.6230	2.026	n.s.
MRC2	7	0.1996	0.2784	1.378	0.0313
P4HA1	6	0.0094	0.0114	1.217	n.s.
P4HA2	5	0.0009	0.0012	1.363	n.s.
P4HA3	8	0.0171	0.0338	1.980	n.s.
P4HB	8	0.2390	0.3264	1.366	0.0234
PCOLCE	7	0.4790	0.5545	1.231	n.s.
PCOLCE2	7	0.0326	0.0107	0.224	0.0313
PLOD1	8	0.0730	0.0985	1.350	n.s.
PLOD2	8	0.0248	0.0380	1.533	n.s.
PLOD3	7	0.0423	0.0419	0.964	n.s.
SERPINH1	8	0.1895	0.2439	1.287	n.s.
SLC39A13	6	0.0538	0.0505	1.022	n.s.
TIMP1	8	0.1956	0.1915	0.979	n.s.

ISSN: 1755-1536