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Table 1 Pathways represented within the microRNA targets common to the set of bleomycin-induced genes

From: MicroRNA profiling implicates the insulin-like growth factor pathway in bleomycin-induced pulmonary fibrosis in mice

Ingenuity canonical pathway Minus log ( P-value) Molecules
Axonal guidance signaling 4.5 EPHA7, ARHGEF12,SOS2,PTCH1,ITGA5,ROBO1,WNT2,EFNB2,FZD4,IGF1,EFNB1,GNA13,PRKD3,ADAM9,NRP1
Role of NANOG in mammalian embryonic stem cell pluripotency 3.65 SOX2,LIF,FZD4,GAB1,SOS2,BMPR2,WNT2
HGF signaling 3.07 ETS1,GAB1,SOS2,MAPK10,ETS2,PRKD3
Cholecystokinin/gastrin-mediated signaling 3.02 ITPR2,SOS2,MAPK10,RHOU,GNA13,PRKD3
Pantothenate and CoA biosynthesis 2.93 PANK1,ENPP1,ENPP5
Molecular mechanisms of cancer 2.82 ARHGEF12,FZD4,GAB1,SOS2,PTCH1,MAPK10,RHOU,BMPR2,HIF1A,GNA13,PRKD3
Endothelin-1 signaling 2.56 EDNRB,GAB1,ITPR2,MAPK10,MAPK6,GNA13,PRKD3
RAR activation 2.49 TAF4 RARB,IGFBP3,MAPK10,NCOR1,PRKD3,PPARGC1A
Mouse embryonic stem Cell pluripotency 2.37 SOX2,LIF,FZD4,SOS2,BMPR2
Phospholipase C signaling 2.35 ARHGEF12,ITPR2,SOS2,RHOU,RPS6KA3,ITGA5,GNA13,PRKD3
IGF-1 signaling 2.31 CTGF,IGF1,SOS2,IGFBP3,GRB10
Hepatic fibrosis/hepatic stellate cell activation 2.31 COL1A2,CTGF,IGF1,EDNRB,FLT1,IGFBP3
ERK5 signaling 2.29 LIF,GAB1,RPS6KA3,GNA13
Glioblastoma multiforme signaling 2.17 FZD4,IGF1,ITPR2,SOS2,RHOU,WNT2
Growth hormone signaling 2.15 IGF1,IGFBP3,RPS6KA3,PRKD3
GDNF family ligand-receptor interactions 2.15 GAB1,ITPR2,SOS2,MAPK10
Renal cell carcinoma signaling 2.11 ETS1,GAB1,SOS2,HIF1A