Table 1 Renal specific factors contributing to kidney fibrosis
From: Fibrosis in the kidney: is a problem shared a problem halved?
| Factor | Cause | |
|---|---|---|
| 1 | Complexity | Kidney consists of ~20 different cell types |
| 2 | Poor capacity for regeneration |
Damaged glomeruli do not regenerate Each nephron is anatomically distinct |
| 3 | Toxins |
Protein leakage and tubule uptake Uraemic milieu (>50 putative or proven toxins) |
| Proteinuria | ||
| Uraemia | ||
| 4 | Hypoxia | High tubule demand for oxygen |
| 5 | Arterial pressure dependent | Pivotal role of renin-angiotensin-aldosterone system |